12. Interleukin-6 Induces Stem Cell Propagation through Liaison with the Sortilin-Progranulin Axis in Breast Cancer
In this article, a novel cancer stem cell activating mechanism was described, mediated by progranulin and IL-6 secretion through activation of the receptor sortilin. Significant correlations were also observed between IL-6 and progranulin secretion using 57 patient-derived scaffold cultures including breast cancer cells, clearly validating the association between IL-6 and progranulin in human-based microenvironments. The dual breast cancer stem cell-promoting function via sortilin, support that sortilin is a highly relevant therapeutic target for aggressive cancer.
