18. The colorectal cancer microenvironment governs clinical behaviors and chemotherapy response
In this ambitious and significant article, Iscaff Pharma’s technology demonstrates that decellularized colorectal patient-derived scaffolds retain key cancer progression traits from the primary cancer niche. Importantly, both scaffold proteins and gene expression changes in adapting cancer cells were further linked to clinical responses to 5FU chemotherapy. In summary, preclinical scaffold techniques in precision medicine can reveal critical cancer-specific and treatment-predictive information.
